一般人群中的血TSH和心血管疾病:一项孟德尔式随机化研究,对105224人进行了随机化研究
Nawar Dalila1, Ruth Frikke-Schmidt2, Børge G Nordestgaard3
1Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Denmark.
Atherosclerosis
|June 1, 2023
概括
低甲状腺刺激激素 (TSH) 水平与心血管疾病风险增加有关,包括心房动和心肌梗塞. 这些关联似乎是因果关系的,突出显示TSH是心脏健康的潜在因素.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
背景情况:
- 心血管疾病风险通常使用临床疾病类别进行评估.
- 甲状腺刺激激素 (TSH) 和心血管事件之间的持续关系需要进一步调查.
研究的目的:
- 为了确定TSH是否与各种心血管疾病的风险有关,在连续规模上.
- 调查TSH和心血管疾病之间的这些观察到的关联是否可能是因果关系.
主要方法:
- 来自哥本哈根一般人口研究的105,224个人的前性队列研究.
- 分析血TSH与发生心血管事件之间的观察相关性.
- 利用遗传风险得分和孟德尔随机化来评估因果关系.
主要成果:
- 较低的TSH度与心房动,心肌梗塞,中风,心力衰竭,大动脉狭窄和主要心血管不良事件的风险更高有关.
- 与50百分位以上的人相比,在第5百分位或更低的TSH个体中,中风和心力衰竭的危险比率明显增加.
- 遗传风险估计表明,较低的TSH与心房动,心肌梗塞和大动脉缩风险增加之间存在潜在的因果关系.
结论:
- 在一般人群中,低血TSH水平与心房动,心肌梗塞和大动脉狭窄的风险增加有关.
- 观察和遗传分析都表明,这些关联可能反映了因果关系的途径.
- TSH可能在特定心血管疾病的发展中发挥直接作用.
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