通过下肢热量暴露来重塑心血管血液动力环境:一项计算流体动力学研究
Zhongyou Li1, Xiao Li1, Fei Yan2
1Sichuan Province Biomechanical Engineering Laboratory, Chengdu, China; Department of Mechanical Science and Engineering, Sichuan University, Chengdu, China.
Computer methods and programs in biomedicine
|June 1, 2023
概括
下肢热量暴露 (LLHE) 通过增加主要动脉和内脏分支的血液流动来改善心血管健康. 这种非药物战略显示出日常使用的潜力,尽管对大动脉血流变化的进一步研究是必要的.
科学领域:
- 心血管生理学心血管生理学
- 热调节 热调节 热调节
- 血液动力学 血液动力学
背景情况:
- 下肢热暴露 (LLHE) 是心血管健康管理的一种非药物策略.
- 了解LLHE对全球血液动力学环境的影响对于其应用至关重要.
研究的目的:
- 检查LLHE对全球血液动力学环境的影响.
- 量化LLHE对皮肤血液流动和全身循环的影响.
主要方法:
- 在健康人群中,在LLHE (40°C和44°C) 之前和之后,在8个下肢位置测量皮肤血流 (SBF).
- 基于SBF变化,利用闭环循环模型评估LLHE对动脉干和内脏动脉血流的影响.
主要成果:
- 在所有测量下肢位置上,LLHE显著增加了SBF,在更高的温度 (44°C与40°C) 中增加更大.
- 循环模型表明,在动脉干中,峰值,终端透气和平均血流的温度依赖的增加.
- 此外,LLHE还增加了内脏动脉的血液流动,并在腹痛期间显著增加了胸部和腹部大动脉的逆向流动.
结论:
- LLHE是一种有前途的日常策略,用于增强动脉干和内脏动脉功能.
- 在胸腔和腹腔大动脉中观察到的血液流量逆转的增加需要进一步调查.
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