慢性血栓栓塞性肺高血压查算法的可行性:OSIRIS研究
Remedios Otero1, José Luis Lobo2, Raquel López3
1Hospital Universitario Virgen del Rocío, Instituto de Biomedicina (IBIS), Sevilla, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Thrombosis research
|June 1, 2023
概括
肺栓塞 (PE) 后慢性血栓栓塞性肺高血压 (CTEPH) 的发生率在两年内为2.49%. 通过使用三步算法确定了早期CTEPH诊断的障碍.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 慢性血栓栓塞性肺高血压 (CTEPH) 是肺栓塞 (PE) 的一个严重的长期并发症.
- 准确的发病率数据和CTEPH的早期诊断策略对于患者的治疗结果至关重要.
研究的目的:
- 确定首次PE发生后两年内CTEPH的发病率.
- 确定实施早期CTEPH诊断结构化三步算法的局限性和障碍.
主要方法:
- 这项OSIRIS研究是一项多中心的纵向队列研究,涉及1191名患者.
- 使用了三步诊断算法,包括问卷,心声学和V / Q光学扫描/右心导管.
- 患者在PE后被跟踪长达24个月.
主要成果:
- 在两年后,CTEPH的累积发病率为2.49% (95% CI:1.68-3.56).
- 发病率为每1000人/月的1.1例.
- 观察到29%的人没有遵守诊断算法,患者和医生的偏好作为障碍. 查问卷显示高特异性 (91.3%) 和NPV (99.4%).
结论:
- 该研究提供了关于PE后CTEPH发病率的临床数据.
- 确定了有效实施CTEPH检测三步分拣算法的障碍.
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