IL-17C中和保护脏免受急性损伤和慢性损伤
Fangfei Zhang1, Jianyong Yin2, Li Liu1
1Department of Rheumatology, Immunology and Allergy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
EBioMedicine
|June 1, 2023
概括
阻断IN-17C (IL-17C) 治疗性地减少了急性损伤 (AKI) 和糖尿病病 (DN) 的损伤. 这项研究表明,IL-17C阻断是这些炎症性脏疾病的有希望的治疗方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 干白素-17C (IL-17C) 是一种细胞因子,与脏疾病的发病有关.
- 以前的研究表明,IL-17C中和可以防止急性损伤 (AKI).
- 这项研究调查了IL-17C在缺血后再注射 (IR) AKI和糖尿病病 (DN) 中的作用.
研究的目的:
- 为了确定在缺血再流损伤 (IRI) 后阻断IL-17C是否为AKI提供治疗益处.
- 探索IL-17C在糖尿病病 (DN) 的发展中的参与.
- 阐明在病中调节IL-17C的信号通路.
主要方法:
- 在AKI模型中,小鼠接受了IL-17C中和抗体或IgG控制后再输血.
- 评估了损伤,炎症和氧化应激.
- 在人类DN患者和db/db小鼠中分析了IL-17C表达;研究了DN进展标志物和信号通路 (NF-κB,HIF-1α).
主要成果:
- 延迟IL-17C中和显示在脏IRI中具有脏保护作用.
- 在DN患者和db/db小鼠中观察到IL-17C表达的增加.
- IL-17C阻塞显著减弱了DN,减少了白膜尿,中扩张和细胞损失.
- 在AKI和DN模型中,IL-17C中和抑制了炎症反应和Th17/IL-17A激活.
- 缺氧或高葡萄糖诱导的IL-17C上调主要由NF-κB途径介导.
结论:
- IL-17C积极参与AKI和DN的病理过程.
- 抑制IL-17C为管理AKI和DN提供了潜在的治疗策略.
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