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预先存在的瘤宿主免疫特征在切除的非小细胞肺癌中

Pedro Rocha¹, Maite Rodrigo², Laura Moliner³

¹Medical Oncology Department, Hospital del Mar - CIBERONC, Barcelona, Spain; IMIM (Instituto Hospital del Mar de Investigaciones Médicas), Barcelona, Spain.

Lung cancer (Amsterdam, Netherlands)

|June 1, 2023

概括

免疫检查点阻塞 (ICB) 是可切除非小细胞肺癌 (NSCLC) 的标准. 瘤免疫微环境 (TIME) 分析显示,CD103+免疫细胞透与早期NSCLC患者的更好的整体存活率 (OS) 有关.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

免疫检查点阻塞 (ICB) 是可切除非小细胞肺癌 (NSCLC) 的标准治疗方法.
需要生物标志物来预测患者在早期NSCLC中对ICB的反应.
瘤免疫微环境 (TIME) 在癌症进展和治疗反应中发挥着关键作用.

研究的目的:

在接受手术的早期NSCLC患者中调查TIME.
在与患者结果相关的时间内识别潜在的生物标志物.
根据组织学和PD-L1表达的基础上探索TIME的差异.

主要方法:

从185名先前未接受过治疗的早期NSCLC患者的瘤组织微阵列分析.
免疫组织化学被用来评估免疫细胞标记物 (CD3,CD4,CD8,CD68,FOXP3,CD103) 和免疫检查点蛋白 (PD-1,PD-L1,PD-L2).
TIME是基于PD-L1表达和CD103+免疫细胞进行分类的;研究了与临床病理特征和整体生存 (OS) 的关联.

主要成果:

肺腺癌 (LUAD) 呈现较高的T细胞和HLA-II表达,而肺状细胞癌 (LUSC) 则具有更多的巨细胞和更高的PD-L1/PD-L2表达.
根据PD-L1,PD-L2和HLA-II类表达,确定了三个不同的瘤子集.
在CD103+/PD-L1+亚组中观察到T细胞,调节性T细胞和巨细胞的丰富.
CD103+免疫细胞的透与改善的生存状况显著相关 (p=0.009).

结论:

时间分析揭示了基于NSCLC组织学和PD-L1表达的独特模式.
CD103+免疫细胞透是一种有前途的生物标志物,可以改善早期NSCLC的存活率.
基于免疫组织化学的TIME评估可能有助于个性化NSCLC患者的辅助治疗策略.

关键词:

历史学历史学历史学在PD-L1中.切除后的NSCLCLC进行了切除.与瘤相关的免疫细胞.

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