认知活动与认知功能随着时间的推移在一个多样化的老年人群中相关,独立于基线生物标志物
Kristin R Krueger1, Pankaja Desai1, Todd Beck1
1Rush Institute for Healthy Aging, Rush University Medical Center, Chicago, Illinois, USA.
Neuroepidemiology
|June 1, 2023
概括
参与认知活动有利于老年人的认知功能,独立于神经生物标志物,如tau,神经丝光 (NfL) 和状纤维酸性蛋白 (GFAP). 这表明认知活动可以促进不同老龄人口的大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 认知心理学 认知心理学
背景情况:
- 认知活动与老年人的认知功能有关,但潜在的机制仍在争论中.
- 目前尚不清楚认知活动是否对认知有好处,或者低活动是否预测认知障碍.
- 神经生物标志物为认知衰老提供了一个新的视角.
研究的目的:
- 调查认知活动,认知功能和老年人的特定神经生物标志物之间的关联.
- 为了确定生物标志物是否通过时间调解或修改认知活动和认知功能之间的关系.
主要方法:
- 一项基于人口的长度研究,对1168名居住在社区的老年人进行研究.
- 通过7项活动的自我报告频率评估认知活动.
- 认知功能通过4项测试的综合得分来衡量.
- 测量了总tau (tau),神经丝光 (NfL) 和状纤维酸蛋白 (GFAP) 的基线度.
主要成果:
- 较高的认知活动与在基线和随着时间的推移更好的认知功能有关.
- 即使考虑到生物标志物,这些关联仍然存在.
- 认知活动与6.4年内认知衰退的减缓有关,NfL和GFAP的减弱最小.
- 生物标志物没有改变认知活动-认知功能关系.
结论:
- 参与精神刺激活动的认知益处似乎独立于基线tau,NfL和GFAP水平.
- 增加的认知活动可能会支持老年人的认知健康,无论其潜在的疾病风险或表现如何.
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