两位病人的肺结核损害了细菌清除,并在无菌炎症期间引起感染
Sergiy Kostenko1, Biswajit Khatua1, Shubham Trivedi1
1Department of Medicine, Mayo Clinic, Rochester, Minnesota.
Gastroenterology
|June 1, 2023
概括
在急性胰腺炎 (AP) 等无菌疾病期间的感染可能是由于细菌清除受损而产生的. 增加的未结合的脂肪酸会破坏免疫细胞的功能,导致细菌过度生长和无菌炎症期间的感染.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 在手术后,过渡性细菌病很常见,但在急性胰腺炎 (AP) 等无菌疾病期间的感染很严重.
- 将无菌炎症与细菌感染联系在一起的机制尚不清楚.
研究的目的:
- 调查细菌清除受损如何导致急性胰腺炎感染.
- 检查非化脂肪酸 (NEFAs) 在这个过程中的作用.
主要方法:
- 分析了AP患者和动物的血液样本,以检测NEFAs,微生物组和炎症标志物.
- 使用热量计研究了巨细胞对NEFA的吸收及其与脂的相互作用.
- 在体内评估了NEFAs对免疫细胞功能和细菌负载的影响.
主要成果:
- 受感染的AP患者和动物显示出高水平的不和,不结合的NEFAs (酸和酸).
- 未结合的NEFAs损害了免疫细胞的细胞和线粒体功能,增加了细菌负载.
- 专可以逆转这些有害影响,而疏水性脂肪酸的效果不那么强.
结论:
- 在无菌炎症期间,循环中高水平的未结合的NEFA可以导致免疫细胞的脂死.
- 这会影响细菌的清除,导致急性胰腺炎等疾病的感染.
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