在割抵抗性前列腺癌对恩扎拉胺耐药性的非编码RNA中
Ke Gao1, Xiaoshun Li2, Jianxin Ni2
1Department of Urology, Xi'an People's Hospital(Xi'an Fourth Hospital), School of Life Sciences and Medicine, Northwest University, Xi'an, 710199, China; The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, 710032, China.
Cancer letters
|June 1, 2023
概括
非编码RNAs (ncRNAs) 在割抵抗性前列腺癌 (CRPC) 中对恩扎胺 (Enz) 的耐药性发展中发挥关键作用. 了解ncRNA失调提供了克服Enz耐药性的新治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 恩扎胺 (Enz) 是对抗割的前列腺癌 (CRPC) 的重要治疗方法.
- CRPC通常会对恩兹产生抗性,因此需要对潜在机制进行研究.
- 非编码RNAs (ncRNAs) 越来越多地被认为对癌症进展和耐药性的作用.
研究的目的:
- 阐明失调的ncRNAs在CRPC进展和Enz耐药性中的作用.
- 审查最近的恩兹耐药性机制,包括ncRNA参与.
- 突出潜在的治疗策略,以ncRNA作为耐酶CRPC的向.
主要方法:
- 在CRPC中对ncRNA进行当前研究的文献综述和综合.
- 机制的分析,包括雄激素受体拼接变体-7 (AR-V7),突变和ncRNA介导的miRNA海绵化.
- 讨论表皮层-介质细胞过渡和葡萄糖代谢在恩兹耐药性.
主要成果:
- 微RNAs (miRNAs),长ncRNAs (lncRNAs) 和圆形RNAs (circRNAs) 的失调有助于CRPC进展和Enz耐药性.
- 作为miRNA海绵的AR-V7,突变和ncRNA是Enz耐药性的关键机制.
- 表皮-介质细胞过渡和改变的葡萄糖代谢也起着重要的作用.
结论:
- ncRNAs是CRPC中恩泽抗性的发展的关键调节者.
- 针对特定的ncRNA和相关途径提供了有前途的治疗途径.
- 对ncRNA功能的进一步研究可以导致针对CRPC治疗失败的新策略.
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