素通过通过HIF-1α通路调节巨细胞氧化应激来减轻狼性炎
Tao Ding1, Tongtong Yi1, Ying Li1
1School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, PR China.
European journal of pharmacology
|June 1, 2023
概括
素 (LUT) 可以通过减少脏炎症和氧化应激来治疗狼性炎 (LN). 它通过抑制巨细胞中的缺氧诱导因子1α (HIF-1α) 途径来起作用,提供了一个潜在的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 狼性炎 (LN) 是系统性红斑狼 (SLE) 的严重并发症,导致显著的死亡率.
- 素 (LUT) 是一种天然化合物,具有抗炎和抗氧化特性,但其在LN中的机制尚未完全理解.
研究的目的:
- 调查性炎 (LN) 中素 (LUT) 的治疗潜力和潜在机制.
- 探索LUT对炎症,氧化应激和LN中缺氧诱导因子1α (HIF-1α) 途径的影响.
主要方法:
- 使用MRL/lpr小鼠和H2O2处理的巨细胞 (Raw264.7) 来研究LUT的影响.
- 分析了人类LN脏样本中HIF-1α表达的GEO数据.
- 进行了体外和体内实验,以评估LUT对功能,氧化应激和HIF-1α信号传递的影响.
主要成果:
- 在MRL/lpr小鼠中,LUT改善了病理异常和改善了功能.
- LUT 降低了脏氧化应激和尿蛋白水平.
- LUT抑制了巨细胞中的HIF-1α表达和氧化应激,减轻了巨细胞诱导的损伤.
结论:
- 缺氧诱导因子1α (HIF-1α) 途径与LUT在LN中的保护作用有关.
- 巨细胞中HIF-1α的升高有助于LN的发病.
- 通过抑制巨细胞中的HIF-1α,LUT显示出作为LN治疗剂的潜力.
更多相关视频
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
111
09:53Herbal Munziq Ameliorates Myocardial Ischemia-Reperfusion Injury by Inhibiting Inflammation
Published on: January 10, 2025
490
相关概念视频
Regulation of Angiogenesis and Blood Supply
2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
Regulation of the Unfolded Protein Response
2.5K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.5K
The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
