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Updated: Jul 28, 2025

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增加P-gp基质的生物可用性:从无形固体分散物中同时释放埃托波和佐苏奎达

Rasmus Blaaholm Nielsen1, Bjarke Strøm Larsen2, René Holm1

  • 1Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense, Denmark.

International journal of pharmaceutics
|June 1, 2023
PubMed
概括

在无形固体分散中与zosuquidar (一种P-gp抑制剂) 共同配制以托化物 (一种P-gp基质),显著提高了口服生物可用性. 这一策略利用同步联合释放来改善药物输送.

关键词:
无形固体的分散性固体.这种类型的Etoposide.基甲基纤维素 (HPMC) 是一种在生物体内,在生物体内.口服生物可用性 口服生物可用性这是一种P-glycoprotein蛋白.聚乙烯罗利 (PVP) 是一种聚乙烯.动物屠杀者是动物屠杀者佐索奎达尔 (LY-335979) 的使用情况

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