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血清中ENA-78水平升高是阻塞性睡眠呼吸暂停和动脉样硬化之间的联系吗?

Artur Nahorecki¹, Andrzej Szuba², Helena Martynowicz³

¹Department of Internal Medicine, St. Lucas Hospital, Jeleniogorska 4, 59-700 Boleslawiec, Poland.

Respiratory physiology & neurobiology

|June 1, 2023

概括

阻塞性睡眠呼吸暂停 (OSA) 患有动脉狭窄症的患者表现出更高的ENA-78血清水平. 这表明,ENA-78可能在与这些患者间歇性缺氧相关的炎症中起作用.

科学领域:

心血管研究的心血管研究.
睡眠的药物睡眠的药物
炎症和免疫学炎症和免疫学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是心血管疾病,炎症和氧化应激的已知危险因素.
动脉狭窄 (CAS) 与OSA共享炎症途径.
了解共享的分子机制对于管理并发病状况至关重要.

研究的目的:

在患有CAS,有或没有OSA的患者中比较各种因素的血清水平.
在OSA的CAS患者中识别潜在的炎症分子媒介.
调查特定因素,如ENA-78在与间歇性缺氧相关的炎症过程中的作用.

主要方法:

招募了68名因CAS而接受手术治疗的患者.
一夜间的测谎仪被用于诊断或排除OSA.
血清水平的促炎性细胞因子,化学和血管因子被测量在早上.

主要成果:

在有和没有OSA的CAS患者之间观察到血清因子水平的显著差异.
ENA-78 (表皮衍生的中性粒细胞吸引剂-78) 血清度显示了两组之间最深刻的差异.
其他测量因素也表现出差异,尽管ENA-78最引人注目的.

结论:

在CAS患者中,具有同时存在的OSA,ENA-78血清度发生显著变化.
在这种患者群体中,ENA-78可能是参与间歇性缺氧的炎症反应的关键分子.
需要进一步的研究来阐明ENA-78在与OSA相关的动脉样硬化中的特定作用.

关键词:

动脉样硬化是一种动脉样硬化.冠状动脉狭窄症是什么细胞因子 (cytokines) 是一种细胞因子.氧气过低是因为缺氧.炎症炎症是一种炎症.阻塞性睡眠呼吸暂停症是什么

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