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患有急性SARS-CoV-2感染的儿童的肝转氨酶度

Madeleine W Sumner¹, Todd A Florin², Nathan Kuppermann³

¹Schulich School of Medicine and Dentistry, Western University, London, Canada.

Clinical biochemistry

|June 1, 2023

概括

与其他呼吸道病毒相比,小儿SARS-CoV-2感染与肝酶 (转氨酶) 升高没有显著的关联. 这项研究发现,在患有或没有SARS-CoV-2的儿童中,阿斯巴酸盐 (AST) 或氨酸转移酶 (ALT) 水平没有差异.

科学领域:

儿童传染病儿童传染病
肝病学肝病学是一种肝病学.
病毒学病毒学

背景情况:

肝损伤是病毒感染的潜在并发症.
SARS-CoV-2 对儿科肝脏健康的影响需要进一步调查.
将SARS-CoV-2与其他常见的呼吸道病毒进行比较对于了解其特定影响至关重要.

研究的目的:

评估SARS-CoV-2感染与儿童肝损伤之间的关系.
为了比较SARS-CoV-2测试的儿童中的转氨酶度与其他呼吸道病毒.
为了确定SARS-CoV-2是否与儿科急诊室环境中的肝酶升高有关.

主要方法:

一项涉及18岁以下儿童的比较研究,在儿科急诊室对SARS-CoV-2或其他呼吸道病毒进行了测试.
使用多变量线性回归分析来比较血清阿斯巴甜酸 (AST) 和氨酸转移酶 (ALT) 度.
从2020年3月至2022年2月期间的两个大型儿科研究网络收集了数据.

主要成果:

在16,892名注册儿童中,4,318人检测出SARS-CoV-2和3,932人其他呼吸道病毒的阳性.
患有SARS-CoV-2的儿童和患有其他呼吸道病毒的儿童之间,转氨酶度没有显著差异.
与阴性呼吸道病毒面板相比,孤立的SARS-CoV-2检测与ALT或AST水平升高无关.

结论:

与其他呼吸道病毒相比,儿童的SARS-CoV-2感染与初始转氨酶度增加无关.
在研究队列中的SARS-CoV-2阳性和阴性儿童之间,转氨酶水平没有显著差异.
在90天的随访期间,在SARS-CoV-2阳性儿童中没有报告新发性肝病.

关键词:

氨基转移酶是一种氨基转移酶.在 COVID-19 疫情中,肝毒性肝毒性肝毒性肝脏中氨酶酶是什么意思儿科儿科儿科这就是SARS-CoV-2病毒.

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