基于工作记忆的决策策略的神经代表在运动和前额叶皮层-基底环中的神经代表
Tomohiko Yoshizawa1,2, Makoto Ito2,3, Kenji Doya4
1Oral Physiology, Department of Oral Functional Science, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan yoshizawa@den.hokudai.ac.jp doya@oist.jp.
eNeuro
|June 1, 2023
概括
像win-stay-lose-switch (WSLS) 这样的简单策略依赖于工作记忆 (WM). 这项研究揭示了大脑中神经回路是如何运作的.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 行为经济学是一种行为经济学.
背景情况:
- 动物和人类的决策通常通过强化学习 (RL) 模型来解释.
- 然而,选择序列经常遵循更简单的基于工作记忆 (WM) 的策略,如win-stay-lose-switch (WSLS).
- 在大脑电路中,这些基于WM的策略的神经支仍然不完全理解.
研究的目的:
- 研究基于工作记忆的选择策略的神经表征,特别是WSLS.
- 检查前额叶和运动皮层-基底结环中的神经元活动如何在决策过程中编码WM信息.
主要方法:
- 在老鼠中开发了一种新的连续/间歇选择任务范式,以操纵工作记忆负载.
- 同时记录了来自背中条体 (DMS),背侧条体 (DLS),中间前额叶皮质 (mPFC) 和初级运动皮质 (M1) 的神经元活动.
- 通过Poisson回归分析神经尖峰数据,以识别先前行动,奖励和WSLS策略的神经编码.
主要成果:
- 行为分析证实了连续状态 (CC) 中一个杂的WSLS策略.
- 神经记录显示,在行动选择之前,在CC中编码了先前的行动和奖励.
- 背侧条纹体 (DLS) 和初级运动皮质 (M1) 显示了工作记忆信息 (以前的选择,奖励和相互作用) 的重要编码,以及当前行动编码.
结论:
- 基于工作记忆的策略,如WSLS,在前额叶和运动皮层-基底质回路中神经代表.
- DLS和M1在维护和利用工作记忆信息进行决策方面发挥着至关重要的作用.
- 这项研究提供了关于简单,记忆引导的选择行为背后的神经机制的见解.
相关概念视频
Role of Cerebellum and Prefrontal Cortex in Memory
508
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
508
Working Memory
390
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
390
Somatosensory, Motor, and Association Cortex
590
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
590
Neural Circuits
1.3K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.3K
Motor and Sensory Areas of the Cortex
4.1K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.1K
Hierarchy of Motor Control
2.9K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
2.9K


