卷曲-卷曲域的细胞外和细胞内功能包含3个
Sara Omari1,2, Hyemin Lee1,2, Jieqiong Wang1,2
1Department of Biochemistry & Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Journal of molecular cell biology
|June 1, 2023
概括
含有3 (CCDC3) 的卷曲-卷曲域是一个具有双重作用的保存蛋白. 它作为血管健康的细胞外因素和乳腺癌的细胞内瘤抑制剂,影响新陈代谢和炎症.
科学领域:
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
- 内分泌学 在内分泌学.
背景情况:
- 含有3 (CCDC3),也称为Favine,是一个由脂肪细胞和内皮细胞分泌的保存蛋白质.
- 在血管系统中,CCDC3表现出类似内分泌的功能.
- 最近的发现强调了CCDC3在乳腺癌中作为核瘤抑制剂的作用.
研究的目的:
- 为CCDC3的多样化功能提供全面的概述.
- 探索其细胞外内分泌类型的作用和细胞内核活动.
- 讨论CCDC3.3的分子机制,临床影响和未来研究方向.
主要方法:
- 文献综述和对CCDC现有研究的综合3.
- 对调查CCDC3参与各种生物过程的研究进行分析.
- 讨论拟议的细胞和分子通路.
主要成果:
- CCDC3在脂质代谢,脂肪肝疾病和腹部肥胖症中起着重要作用.
- 该蛋白质表现出抗炎性质,并与动脉样硬化有关.
- 在乳腺癌的背景下,CCDC3作为瘤抑制剂起作用.
结论:
- CCDC3是一种多功能蛋白质,在代谢和瘤途径中起着关键作用.
- 了解CCDC3的双重细胞外和细胞内功能对于治疗开发至关重要.
- 需要进一步的研究才能充分阐明CCDC3的机制和临床潜力.
相关概念视频
Conservation of Protein Domains Over Different Proteins
11.0K
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.0K
Cytoskeletal Accessory Proteins
3.1K
The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
3.1K
Coat Assembly and GTPases
3.6K
Vesicles incorporate different coat protein subunits in different cell locations, which changes the properties of the coat, such as the shape and geometry of the transport vesicles. Thus, vesicle coat proteins also play a significant role in cargo selection.
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
Coat assembly depends on the local availability of phosphatidylinositol phosphates or PIPs and GTP-binding proteins. Adaptor proteins, which link the coat proteins to the membrane, bind to these PIPs and play a crucial role in controlling...
3.6K
Assembly of Signaling Complexes
5.8K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
5.8K
Structural Protein Function
27.9K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
27.9K
Intrinsically Disordered Proteins
2.4K
2.4K


