用于UGN-101的管理途径和对瘤和安全结果的影响
Jennifer Linehan1, Josh Gottlieb2, Solomon L Woldu2
1Providence Specialty Medical Group, Santa Monica, CA, USA.
European urology focus
|June 1, 2023
概括
在上道泌尿道癌 (UTUC) 的UGN-101前级治疗中,与逆行途径相比,收缩率较低. 这种方法保持了UTUC治疗的瘤疗效.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- UGN-101是一种化疗剂,用于低级上道泌尿道癌 (UTUC) 的化疗.
- 给药途径包括通过尿管导管进行逆行或通过瘤管进行前行.
研究的目的:
- 根据给药途径,比较UGN-101治疗的结果.
- 评估每种输送方法的瘤反应和尿管狭窄发生情况.
主要方法:
- 在15个机构对132名低度UTUC患者进行了回顾性审查,这些患者接受了UGN-101治疗.
- 逆行与前退行给药途径的比较,分析治疗,并发症和每种单元的复发情况.
主要成果:
- 完全响应率相似:48%的逆行相对于60%的前行 (p=0.1).
- 克拉维恩3级尿路收缩在前级 (12%) 和后级 (32%) (p<0.01) 相比,在前级 (12%),显著降低.
- 限制包括潜在的治疗偏差,前期患者更有可能接受先前的内镜切除.
结论:
- 对于UTUC,UGN-101的前期管理与尿管收缩的显著降低率有关.
- 服用途径似乎不会影响UGN-101在治疗低度UTUC的瘤疗效.
更多相关视频
09:02Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
Published on: September 27, 2024
2.7K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
相关概念视频
01:18Additional Routes of Drug Administration
2.9K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.9K
01:22Routes of Drug Administration: Overview
6.4K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
6.4K
01:18Drug Delivery: Enteral Route
528
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
528
01:26Enteral Nutrition I: Orogastric and Nasogastric Feeding
384
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
384
01:22Drug Delivery: Miscellaneous Routes
409
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
409
01:16Drug Delivery: Overview
333
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
333