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超声波相对逆向散射和衰减系数的同时成像,用于定量性肝硬化症评估

José Timaná¹, Hector Chahuara¹, Lokesh Basavarajappa²

¹Laboratorio de Imágenes Médicas, Pontificia Universidad Católica del Perú, Lima, Peru.

Scientific reports

|June 1, 2023

概括

定量超声波 (QUS) 有效地检测非酒精性脂肪性肝病 (NAFLD) 在老鼠中的进展. 这种非侵入性成像方法对早期NAFLD评估和监测肝硬化有前途.

科学领域:

医疗成像医学成像
肝病学肝病学是一种肝病学.
生物医学工程生物医学工程

背景情况:

肝病的患病率正在上升,非酒精性脂肪性肝病 (NAFLD) 是主要原因.
准确和早期评估肝脏肥胖症对于管理NAFLD进展至关重要.

研究的目的:

开发和验证一种定量超声波 (QUS) 成像方法,用于检测NAFLD中肝肥胖症的进展.
为了估计脂肪分数和分类肥胖症等级,使用QUS进行非侵入性测量.

主要方法:

55只大鼠被食以控制或缺乏甲胺-胆 (MCD) 的饮食来诱导NAFLD.
在第2周和第6周进行了超声波 (US) 测量,随后进行了组织学分析.
使用相对逆向散射,衰减系数和信号与噪声比来训练回归模型,用于脂肪分数估计和脂肪酸分级.

主要成果:

基于QUS的回归模型实现了高的确定系数 (R2 = 0.97,p < 0.01) 和低的RMSE (3.64) 脂肪分数估计.
肝硬化等级的分类显示出高精度 (94.55%).
在体内QUS提供了可靠的肝脏肥胖症的定量评估.

结论:

定量超声波 (QUS) 是一种有前途的非侵入性成像技术,用于早期评估NAFLD.
通过QUS,可以准确地在体内监测肝脏肥胖症的进展.
这种模式可能有助于NAFLD的临床管理和研究.

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