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Updated: Jun 26, 2026

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间接的CRISPR查与光转换揭示了药物耐药性的关键因素与细胞-细胞相互作用

Keisuke Sugita1, Iichiroh Onishi1, Ran Nakayama1

  • 1Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.

Communications biology
|June 1, 2023
PubMed
概括

研究人员开发了间接的CRISPR查,以确定影响癌症药物耐药性的支持细胞. 这种方法揭示了关键基因,为改善癌症治疗结果提供了新的治疗点.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...