由Cutibacterium avidum产生的新型循环细菌素阿维杜米辛 (Avidumicin) 显示出抗Cutibacterium的活性
Juri Koizumi1, Keisuke Nakase1, Norihisa Noguchi1
1Department of Clinical Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.
The Journal of antibiotics
|June 1, 2023
概括
导致的细菌中的抗菌素耐药性正在上升. 一种皮肤细菌,Cutibacterium avidum,产生一种新型化合物,阿维杜米辛,有效抑制这种生长,提供一种潜在的新治疗方法.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 生物化学 生物化学
背景情况:
- 在Cutibacterium acnes (Cu. 需要替代性治疗.
- 结合性皮肤细菌可以调节皮肤微生物组,并抑制病原体的过度生长.
研究的目的:
- 为了识别皮肤细菌与抗Cu. 活动活动. acnes活动.
- 描述这些细菌产生的抗微生物化合物.
主要方法:
- 对122种皮肤细菌分离物的查,以检测对Cu的生长抑制. . . . 没有.
- 活跃和不活跃菌株的比较基因组分析.
- 基因集群克隆和合成以确认抗菌活性.
主要成果:
- 昆虫细菌 (Cutibacterium avidum) (Cu.Avidum) 是一种植物,可以生长长长久的植物. ) 和大多数临床分离物抑制了Cu. 的生长. 的生长.
- 一种新的循环细菌素,阿维杜米辛,在Cu.中被发现. 这就是Avidum.
- 艾维杜米辛证明已证实抗Cu. 的活动,可能通过其C端区域.
结论:
- 这就是Cu.Cu. 阿维杜姆 (avidum) 产生了阿维杜米辛 (avidumicin),这是一种新型循环细菌素,具有特定的抗Cu. 活动活动. acnes活动.
- 阿维杜米辛显示出作为的替代治疗剂的潜力.
- 这一发现突显了开始性皮肤细菌及其产品的治疗潜力.
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