甲状腺功能与regorafenib在患有复发性野生型IDH质母细胞瘤的患者中的疗效之间的关联:一项大型多中心研究
Mario Caccese1, Isacco Desideri2, Marta Padovan3
1Department of Oncology, Oncology 1, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy. mario.caccese@iov.veneto.it.
Journal of neuro-oncology
|June 1, 2023
概括
甲状腺激素水平,特别是FT3/FT4比率和TSH,可以预测使用regorafenib治疗的质母细胞瘤复发患者的结果. 较低的TSH与疾病进展相关,而fT3/fT4比率显示出非线性生存相关性.
科学领域:
- 神经瘤学神经瘤学
- 内分泌学 在内分泌学.
- 癌症生物标志物 癌症生物标志物
背景情况:
- 雷戈拉芬尼在复发性质母细胞瘤 (GBM) 中表现有前途.
- 甲状腺激素 (fT3,fT4,fT3/fT4比率) 是各种癌症的潜在预后因素.
- 在接受regorafenib治疗的GBM患者中调查甲状腺变量至关重要.
研究的目的:
- 探索基线甲状腺功能与接受regorafenib的IDH野生型GBM患者的结果之间的关系.
- 为了确定甲状腺激素水平是否可以预测治疗反应和存活率.
主要方法:
- 对128名IDH野生型GBM患者的回顾性分析,这些患者接受了regorafenib治疗.
- 基线甲状腺功能测试的评估 (TSH,FT3,FT4,FT3/FT4比率).
- 使用卡普兰-梅尔和考克斯回归模型进行生存分析.
主要成果:
- 无进展生存时间 (PFS) 中位数为2.7个月;总生存时间 (OS) 中位数为10.0个月.
- 较低的TSH基线水平与疾病进展的增加相关 (p=0.04).
- 在基线fT3/fT4比率和PFS (p=0.01) 和OS (p=0.03) 之间观察到非线性关系.
结论:
- 基线fT3/fT4比率与复发性IDH野生型GBM的存活率有非线性关联.
- 基线TSH可以作为预测该患者群体中regorafenib疗效的指标.
- 甲状腺功能需要进一步调查,作为GBM的预后标志物.
关键词:
质母细胞瘤 (glioblastoma) 是一个雷戈拉费尼布的使用情况甲状腺是什么?甲状腺是什么?fT3 / fT4 / fT3 / fT4 / fT4 / fT3 / fT4 / fT3 / fT4 / fT4 / fT3 / fT4 / fT3 / fT4 / fT4 / fT3 / fT4 / fT4 / fT3 / fT4 / fT4 / fT4 / fT3 / fT4 / fT4 / fT3 / fT4 / fT4 / fT3 / fT4 / fT4 / fT4 / fT3 / fT4 / fT4 / fT4 / fT4 / fT3 / fT4 / fT4 / fT4 / fT4 / fT3 / fT4 / fT4 / fT4 / fT3 / fT4 / fT4 / fT4 / fT4 / fT4相关概念视频
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