透析开始时血清水平与全因死亡率之间的关系
Yuji Sasakawa1, Yoshitaka Tatematsu1, Joichiro Kato1
1Department of Internal Medicine, Department of Nephrology, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, Aichi, 4548509, Japan.
Clinical and experimental nephrology
|June 1, 2023
概括
在透析开始时的低血清或低血清与慢性病患者的死亡率增加有关. 及时识别和治疗低血症对于改善患者的结果至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 低血是慢性病 (CKD) 患者的常见并发症.
- 这种电解质失衡与较高的死亡率有关,特别是在接受透析的患者中.
- 关于低血的死亡风险的研究有限,特别是在开始透析的患者中.
研究的目的:
- 调查透析开始时血清水平与全因死亡率之间的关联.
- 确定发生透析患者中低血的预后意义.
主要方法:
- 一项前性队列研究包括1520名开始透析的患者.
- 患者被分为五个血清分组:<130,130-134,135-139,140-144和≥145mEq/L.
- 多变量Cox比例危险模型被用于分析与所有原因死亡率相关的因素.
主要成果:
- 在随访期间,共有392人死亡.
- 血清水平最低 (<130 mEq/L) 和最高 (≥145 mEq/L) 的患者表现出更高的超过体积.
- 与135-139mEq/L (HR: 1.61,95%CI: 1.04-2.49) 相比,血清<130mEq/L的患者的全因死亡风险显著增加.
结论:
- 透析开始时的低血 (<130mEq/L) 是所有原因死亡率的重要预测因素.
- 诸如心血管疾病和药物使用等潜在疾病可能会导致这种关联.
- 这些发现强调了在开始透析的患者中监测和管理血清水平的重要性.
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