在东亚人群中,慢性乙型肝炎和COVID-19之间的因果关系
Zhenguo Liu1, Linnan Song1, Junling Chen1
1State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou, 510515, China.
Virology journal
|June 1, 2023
概括
慢性乙型肝炎 (CHB) 增加了感染SARS-CoV-2和住院治疗COVID-19的风险. 这项研究利用门德尔的随机化来建立因果关系,提供了对COVID-19易感性和严重性的见解.
科学领域:
- 遗传学和传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,慢性乙型肝炎 (CHB) 和2019年新冠肺炎疾病 (COVID-19) 之间存在不一致的关联.
- 门德尔随机化 (MR) 用于调查潜在的因果关系,克服传统观测研究的局限性.
研究的目的:
- 确定CHB和COVID-19结果之间的总和直接因果关系.
- 评估CHB是否影响COVID-19感染的易感性和严重性.
主要方法:
- 进行了单变量和多变量门德尔随机化 (MR) 分析.
- 针对CHB和COVID-19的全基因组关联研究 (GWAS) 数据集来自日本生物银行和COVID-19宿主遗传学倡议.
- 进行了敏感性分析,以确保结果的可靠性.
主要成果:
- 单变MR表示CHB显著增加了SARS-CoV-2感染,住院COVID-19和严重COVID-19的风险.
- 在对2型糖尿病和BMI等因素进行调整后,多变量MR证实了CHB与SARS-CoV-2感染和住院COVID-19的积极关联.
- 在多变量MR中,CHB和严重的COVID-19之间的因果关系被减弱;没有发现COVID-19对CHB的因果作用.
结论:
- 慢性乙型肝炎与COVID-19的易感性和严重性增加有因果关系.
- 这些发现对于东亚血统的个人来说尤为重要.
- 该研究强调了在COVID-19风险评估中考虑CHB状态的重要性.
相关概念视频
Causality in Epidemiology
512
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
512
Single Nucleotide Polymorphisms-SNPs
15.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.3K
Bias in Epidemiological Studies
388
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
388
Psychoneuroimmunology: Cardiovascular Disease
57
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
57
Mechanisms of Retrovirus-induced Cancers
5.2K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.2K
Diseases of the Liver and Gallbladder
705
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
705


