线粒体功能障碍和糖尿病中的性变态:来自基于人口的队列研究的证据
Shanjie Wang1,2, JunChen Guo1,2, Xiaoxuan Liu1,2
1Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Diabetology & metabolic syndrome
|June 1, 2023
概括
被诊断为2型糖尿病的男性面临与线粒体代谢物甲基马龙酸 (MMA) 相关的更高死亡风险. 这项研究强调了与糖尿病相关的死亡率和MMA的性别特异性差异.
科学领域:
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
- 老年学是一门学科.
背景情况:
- 糖尿病病理生理学的基于性别的差异尚未得到充分理解.
- 线粒体功能障碍,以甲基马龙酸 (MMA) 积累为标志,在性别特异性疾病反应中起作用.
- 调查MMA与2型糖尿病或没有2型糖尿病的成年人死亡风险的关联至关重要.
研究的目的:
- 检查成年人死亡风险和甲基马龙酸 (MMA) 水平之间的性别特定关联.
- 为了确定这些关联是否根据糖尿病状态 (没有,糖尿病前期,被诊断) 不同.
主要方法:
- 一项对24,164名成年人进行的队列研究 (NHANES, 1999-2014年) 使用基线MMA测量.
- 参与者按糖尿病状况分类:没有糖尿病,糖尿病前期,未诊断的糖尿病和已诊断的糖尿病.
- 截至2015年12月31日确定的死亡率数据.
主要成果:
- 男性的死亡率高于女性,特别是在被诊断为2型糖尿病时.
- 在MMA和死亡风险之间发现了显著的性别特异性相互作用,但仅在被诊断为糖尿病患者中 (p=0.028).
- 较高的MMA水平与全因死亡风险增加有关,在被诊断为糖尿病的男性中 (HR 1.58) 与女性 (HR 1.19) 相比,观察到的过度风险更大.
结论:
- 在被诊断为2型糖尿病时,死亡风险的性别差异明显.
- 甲基马龙酸 (MMA) 的升高与未来死亡率的增加有关,患有糖尿病的男性比女性面临更大的风险.
- 在被诊断的2型糖尿病中,MMA与死亡率的关联取决于性别.
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