在一般人群中对高敏感性热波宁和死亡率的研究
John W McEvoy1,2,3, Natalie Daya3, Olive Tang2
1University of Galway School of Medicine and National Institute for Prevention and Cardiovascular Health, Moyola Lane, Newcastle, Galway H91-FF68, Connacht, Ireland.
高灵敏度的心脏托罗宁测定显示了适度的相关性. 心脏热素I测定为一般人群提供了独特的死亡风险信息,独立于其他测定.
科学领域:
- 心脏病学 心脏病学
- 生物标志物研究 生物标志物研究
- 公共卫生 公共卫生
背景情况:
- 高灵敏性心脏热血素T (hs-cTnT) 和心脏热血素I (hs-cTnI) 是重要的生物标志物.
- 存在多种hs-cTn试验,需要进行比较分析.
研究的目的:
- 评估四个hs-cTn试验 (一个T,3个I) 之间的相关性.
- 评估这些试验与所有原因和心血管死亡率的比较关联.
主要方法:
- 分析了NHANES (1999-2004) 中没有心血管疾病的9810名成年人的数据.
- 对hs-cTnT (罗氏) 和hs-cTnI (阿博特,西门子,奥托) 的测量.
- 考克斯回归以确定与死亡率的关联,相关系数从0.53到0.77.
主要成果:
- 所有四个hs-cTn试验都独立地与增加全因和心血管死亡率有关.
- 在调整为hs-cTnI后,hs-cTnT的关联仍然很重要.
- hs-cTnI测定提供了不同的死亡风险信息,即使在相互调整后.
结论:
- 在hs-cTnT和hs-cTnI试验之间存在适度的相关性.
- hs-cTnI测定为一般人口的死亡率提供了独特的预后价值.
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