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阳性气道压力疗法使用者的呼吸道感染风险:回顾性队列研究
Ronald Gavidia1, Monica M Shieu1, Galit Levi Dunietz1
1Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan.
概括
对睡眠呼吸暂停的积极气道压力 (PAP) 治疗不会增加呼吸道感染的风险. 这项研究发现PAP使用与感染率增加之间没有关联,这可能缓解了患者对PAP设备使用的担忧.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
- 流行病学 流行病学
背景情况:
- 对可能增加呼吸道感染 (RI) 风险的正气压 (PAP) 治疗的担忧会影响患者对PAP设备使用和维护的决定.
- 有限的数据存在于PAP使用和发展RI的风险之间的时间关系.
研究的目的:
- 在一组被诊断患有阻塞性睡眠呼吸暂停 (OSA) 的患者中调查使用PAP治疗与临床显著RI风险之间的纵向关联.
主要方法:
- 一项回顾性队列研究分析了482名接受PAP定位的成年OSA患者.
- 通过临床记录确定了呼吸道感染 (RIs) 从PAP定位前两年到PAP定位后两年的临床记录.
- 经对共变量进行调整的Poisson回归模型评估了PAP使用/坚持和随后的RI率之间的关联.
主要成果:
- 经调整的波桑回归模型显示,PAP治疗使用率和PAP后RI率之间没有统计学上显著的关联 (比率比率=1.27,95%CI:0.86-1.86).
- 专注于PAP坚持度的灵敏度分析产生了类似的非显著结果 (比率比率=0.65,95%CI:0.32-1.30).
结论:
- 该研究没有发现证据表明PAP使用或坚持与OSA的成年人呼吸道感染的频率增加有关.
- 这些发现可能有助于缓解患者对呼吸道感染风险的担忧,可能减少在开始或坚持PAP治疗时的犹.
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