一个单一机构的儿科和年轻成人干预瘤学合作:针对复发/耐药固体瘤的新型治疗选择
Raja Shaikh1, Brent R Weil2,3, Christopher B Weldon2,3
1Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Cancer medicine
|June 2, 2023
概括
儿科干预瘤手术为儿科瘤提供了有效的治疗方法,显示出显著的反应率和改善患者功能. 需要进一步的多机构试验来确认长期的疗效和耐用性.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 儿科 儿科 儿科
背景情况:
- 儿科干预瘤学 (PIO) 是治疗儿科瘤的一个新兴领域.
- 关于PIO中统一的治疗方案和疗效终点的数据有限.
研究的目的:
- 评估干预性放射学手术在患有良性和恶性瘤的儿科患者的安全性和有效性.
- 为了评估放射性反应,疼痛减轻和功能改善.
主要方法:
- 一项合作倡议收集了40名儿科患者 (16名恶性,24名良性) 的数据,这些患者正在接受治疗性干预放射学手术.
- 在固体瘤中使用修改响应评估标准 (mRECIST) 进行放射性响应评估.
- 追踪了疼痛和功能终点,并计算了进展性疾病的累积发病率.
主要成果:
- 大约40%的恶性和60%的良性瘤患者实现了完全/部分反应或稳定的疾病.
- 没有患者经历过进展性疾病,这是他们最好的反应.
- 观察到疼痛,运动和活动水平的显著改善,只有轻微的并发症.
结论:
- 干预性放射学指导干预是小儿瘤的可行的替代或补充治疗方法.
- 未来的多机构试验对于进一步定义效用,终点和耐用性至关重要.
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