童年不可预测性后大脑结构的异常:抑郁和焦虑症状背后的一个机制
Zhengxinyue Wang1,2, Xinyu Cao1,2, Xiaoyu Zheng1,2
1Center for Cognition and Brain Disorders of Affiliated Hospital, Hangzhou Normal University, Hangzhou, China.
Psychological medicine
|June 2, 2023
概括
儿童时期的不可预测性,与创伤不同,与大脑灰质体积 (GMV) 的改变有关. 这种转基因病毒变化可能解释了不可预测性如何导致年轻人的抑郁和焦虑症状.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 众所周知,童年的逆境会影响大脑结构.
- 儿童时期的不可预测性,一种特定的逆境,以前没有与大脑结构相关的研究.
- 研究童年不可预测性对神经发育的独特影响至关重要.
研究的目的:
- 检查灰质体积 (GMV) 异常是否调解了童年不可预测性和精神病理之间的联系.
- 要确定这些影响是否独立于童年创伤.
- 探索与童年不可预测性相关的精神病理背后的神经机制.
主要方法:
- 158名健康的年轻成年人 (17-28岁) 接受了结构性MRI.
- 参与者提供了关于童年不可预测性的回顾性报告.
- 心理病理的评估是使用简要症状目录-53.3的焦虑和抑郁分量级来评估的.
主要成果:
- 童年不可预测性与多个大脑区域的GMV增加相关,包括前极,前和后中心,即使控制了童年创伤.
- 发现双边前极,前和后中心环中的GMV增加调解了不可预测性和抑郁/焦虑症状之间的关系.
- 确定的特定区域包括双边前极,前,后中心,右状和舌状,以及左腹侧前额和后额皮层.
结论:
- 童年的不可预测性对神经发育有独特的影响,与童年创伤分开.
- 特定大脑区域的GMV变化可能是将童年不可预测性与精神病理联系起来的机制.
- 这些发现对理解和干预来自不可预测的童年环境的心理健康问题有影响.
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