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Updated: Jul 28, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

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一个ERK5-NRF2轴调解衰老相关的干和动脉样硬化

Jun-Ichi Abe1, Masaki Imanishi1, Shengyu Li2

  • 1Departments of Cardiology (J.-i.A., M.I., K.A.K., V.S.K.S., L.-L.L., A.P.B., Y.J.G., A.D., N.L.P., K.F., S. Kotla), The University of Texas MD Anderson Cancer Center, Houston, TX.

Circulation research
|June 2, 2023
PubMed
概括

ERK5酸化将髓状细胞重新编程为衰老的表型,导致动脉样硬化. 抑制ERK5 S496酸化可降低这一过程,为炎症性疾病提供新的治疗点.

关键词:
与NF-E2相关的第2因子 (NRF2)抗氧化剂 抗氧化剂是一种抗氧化剂.动脉样硬化 动脉样硬化基因激活蛋白激酶7 (ERK5) 的作用.接收器,阿里碳水化合物 (AHR).与衰老相关的分泌表现型化和化 化和化

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