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Updated: Jul 28, 2025

Single-Molecule Dwell-Time Analysis of Restriction Endonuclease-Mediated DNA Cleavage
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机械洞察AP-endonuclease 1在停滞的复制叉上模仿基基部位的切割

Nicole M Hoitsma1, Jessica Norris2, Thu H Khoang1

  • 1Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

Nucleic acids research
|June 2, 2023
PubMed
概括

AP内核酶1 (APE1) 在复制分叉处有效地处理单链DNA (ssDNA) 中的基基位,即使与复制蛋白A (RPA) 结合. 这揭示了对DNA修复机制和复制叉稳定性的关键分子见解.

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