患有头癌的非老年患者的脆弱性
Ajay T Bakas1, Harmke A Polinder-Bos2, Fleur Streng2
1Department of Otorhinolaryngology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
概括
老年8 (G8) 工具有效地识别了年轻头癌 (HNC) 患者的脆弱性. 脆弱的HNC患者面临着明显更高的死亡风险,这突出了G8的情况.
科学领域:
- 老年瘤学 老年瘤学
- 头癌研究研究 头癌研究
- 在癌症患者的脆弱性评估.
背景情况:
- 头癌 (HNC) 患者经常出现不良的生活方式因素和并发症.
- 老年8 (G8) 已被验证用于识别老年癌症患者的脆弱性.
- 有限的数据存在于年轻HNC人群的脆弱性评估.
研究的目的:
- 评估老年8 (G8) 工具在年轻HNC患者 (70岁以下) 中识别脆弱性的有效性.
- 确定G8确定的脆弱性与这一人口群中的死亡率之间的关联.
主要方法:
- 在第三级癌症中心进行了一项病例控制研究.
- 使用G8工具评估70岁以下的HNC患者;得分≤14表示脆弱.
- 脆弱的患者与基于性别,年龄,吸烟状况,瘤位置和咨询时间的非脆弱对照进行了匹配.
主要成果:
- 45名虚弱患者 (G8 ≤14) 与90名非虚弱对照进行了匹配.
- 虚弱的患者表现出较低的BMI,教育水平,更差的WHO绩效状态和自我报告的健康状况.
- 在脆弱患者 (28.9%) 的1年死亡率明显高于非脆弱对照 (10%) 的1年死亡率,危险比为3.87 (p=0.014).
结论:
- 老年8 (G8) 查工具是一种有效的方法,用于识别年轻的头癌患者的脆弱性.
- 由G8确定的脆弱性与该人口的死亡风险增加有显著关联.
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