在瘤发生过程中,还原和表观遗传系统之间的交叉调节:分子机制和临床应用
Xiao Zhang1,2, Lifang Ma1,2, Jiayi Wang1,2
1Department of Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China.
Antioxidants & redox signaling
|June 2, 2023
概括
氧化和表观遗传学是癌症的关键调节者. 它们的相互作用影响瘤生长和死亡,提供了潜在的新治疗点.
科学领域:
- 分子生物学分子生物学
- 癌症研究 癌症研究
- 生物化学 生物化学
背景情况:
- 细胞的氧化还原平衡主要受到活性氧物种 (ROS) 的影响,对生理功能至关重要.
- 在癌症中,ROS就像一把双刃剑,在低水平上促进瘤生长,在高水平上诱导细胞死亡.
- 表观遗传机制,包括DNA甲基化,基因素修饰和非编码RNA,显著影响氧化还原平衡.
研究的目的:
- 审查癌症发展过程中氧化还原过程和表观遗传机制之间的复杂交叉调节.
- 阐明这种相互作用背后的分子机制.
- 讨论针对癌症治疗中的氧化还原-表观遗传交叉的当前和未来临床应用.
主要方法:
- 对研究的综合文献综述,研究了癌症中氧化还原和表观遗传学之间的关系.
- 对连接活性氧物种 (ROS) 和表观遗传修饰的分子机制的分析.
- 对临床应用和未来方向的现有研究进行评估.
主要成果:
- 氧化还原平衡受到各种表观遗传因素的调节,包括DNA甲基化,基因质修饰和非编码RNA.
- 氧化和还原剂可以改变表观遗传的景观.
- 反氧化和表观遗传学之间的双向交叉声在瘤启动,进展和细胞死亡途径 (亡,铁亡,死亡,热亡) 中发挥着关键作用.
结论:
- 反氧化和表观遗传学之间的交叉调节是癌症生物学的一个基本方面.
- 了解这些分子机制对于开发新的癌症治疗方法至关重要.
- 未来的研究应该采用高通量方法来进一步揭示这些复杂的相互作用,以改善临床指导.
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