探索COVID-19住院治疗后持续的神经认知后果的危险因素
Peter Y Ch'en1, Laura S Gold2, Qiongshi Lu3
1Albert Einstein College of Medicine, Bronx, New York, USA.
Annals of clinical and translational neurology
|June 2, 2023
概括
较低的社会经济地位和先前存在的焦虑增加了发展神经PASC (SARS-CoV-2感染的急性后续症) 的风险. 女性性别和西班牙裔种族与COVID-19住院后的认知障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2感染 (PASC) 的后急性后续包括急性感染后的一系列持续症状.
- 神经认知障碍或神经PASC是影响COVID-19住院后个体的一个重大问题.
- 识别神经PASC的风险因素对于理解其发展和为临床管理提供信息至关重要.
研究的目的:
- 确定与急性SARS-CoV-2感染住院患者中神经PASC发展相关的风险因素.
- 在6个月的随访中调查社会人口学因素,先前存在的焦虑和持续的神经认知症状之间的关联.
主要方法:
- 进行了一项探索性,观察性单中心队列研究,其中89名参与者因COVID-19住院治疗.
- 持续的神经认知症状被定义为1个月存在的症状,并在感染后持续6个月.
- 使用多变量逻辑回归分析来确定神经PASC的潜在风险因素.
主要成果:
- 60%的参与者在6个月后报告持续的神经认知症状,疲劳是最常见的 (53%).
- 较低的社会经济地位和较高的COVID-19前焦虑评分与发展神经PASC的几率增加有关.
- 女性性别和西班牙裔种族与持续认知功能和能力受损的可能性增加有关.
结论:
- 社会人口结构因素和COVID-19前的焦虑是神经PASC的潜在风险因素.
- 病前精神健康症状可能预测SARS-CoV-2感染后持续的神经认知症状.
- 进一步的研究应该在PASC研究和临床评估中评估这些因素.
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