Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Humoral Immune Responses

Humoral Immune Responses

Antibody Actions

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Multivalent DNA vaccines induce potent cellular responses and prolong BCG-mediated control of Mycobacterium tuberculosis.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

Corrigendum to "The S2 glycoprotein subunit of porcine epidemic diarrhea virus contains immunodominant neutralizing antibodies". [Virol. 509 [2017] 185-194].

Virology·2026

Same author

Engineering single-dose plasmid DNA for sustained in vivo delivery of designer incretins.

Trends in biotechnology·2026

Same author

Efficient in vivo assembly of DNA encoded polyvalent BTEs for dual antigen targeting for broadening therapeutic impact in ovarian cancer.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Same author

Single-cell transcriptomics reveal altered B cell responses and T cell senescence in geriatric non-responders to COVID-19 mRNA vaccination.

iScience·2026

Same author

Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination.

Proceedings of the National Academy of Sciences of the United States of America·2026

Search research articles

相关实验视频

Updated: Jul 28, 2025

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

用于广泛中和抗体的输送平台.

Lok R Joshi¹, Nicolás M S Gálvez¹, Sukanya Ghosh²

¹Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts.

Current opinion in HIV and AIDS

|June 2, 2023

概括

基于基因的广泛中和抗体 (bNAbs) 提供了一个有希望的替代方案,用于预防和治疗艾滋病毒的被动抗体管理. 在DNA,mRNA和病毒载体技术的进步正在克服有效的HIV干预措施的局限性.

科学领域:

免疫学和病毒学
基因治疗和生物技术

背景情况:

更多相关视频

Laboratory Scale Production and Purification of a Therapeutic Antibody

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

相关实验视频

Last Updated: Jul 28, 2025

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Laboratory Scale Production and Purification of a Therapeutic Antibody

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

广泛中和抗体 (bNAbs) 的被动管理是预防和治疗艾滋病毒的一种策略.
目前被动转移的挑战包括需要定期管理.
基于基因的传递方法正在开发中,以克服这些局限性.

结论:

基于基因的bNAbs的输送对艾滋病毒治疗和预防具有重大潜力.
基因传递效率和降低免疫性方面的进一步进展对于广泛实施至关重要.
克服基因bNAb传递的技术挑战,为实现实际的艾滋病毒干预提供了明确的途径.