营养状况与抗癌免疫的关系及其对头癌的预后价值

相关实验视频

Updated: Jul 28, 2025

09:01

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

457

Miao-Fen Chen¹, Yu-Yen Chen², Wen-Cheng Chen²

¹Department of Radiation Oncology, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan.

Molecular carcinogenesis

|June 2, 2023

概括

头癌 (HNC) 患者的营养不良与较差的结果和抗癌免疫力减弱有关. 营养支持可以通过增强免疫反应来改善预后,如患者数据和动物模型所示.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
营养科学营养科学

背景情况:

营养不良在头癌 (HNC) 患者中很常见,通常与生存率降低和抗癌免疫力受损有关.
了解营养状况,免疫反应和HNC的预后之间的相互作用对于改善患者的治疗结果至关重要.

研究的目的:

研究通过患者生成主观全球评估 (PG-SGA) 评估的营养状况与HNC患者的免疫因素之间的关系.
确定HNC的营养状况的预后值及其与抗癌免疫反应的相关性.
在临床前模型中评估营养补充对瘤发育和免疫微环境的影响.

主要方法:

对212名接受PG-SGA和治愈性放射治疗 (RT) 的HNC患者进行了回顾性审查.
对免疫标记物的分析,包括中性粒细胞与淋巴细胞的比率,髓质衍生抑制细胞 (MDSC) 和IL-6水平.
利用4-尼托基诺林1-氧化物 (4NQO) 诱导的舌头瘤动物模型来评估营养补充剂对瘤形成和免疫反应的影响.

主要成果:

较高的PG-SGA分数 (表明营养不良) 与更先进的疾病,更低的BMI,减少RT完成和更差的生存率有关.
营养不良的患者表现出高的中性粒细胞和淋巴细胞比率,增加的MDSCs和更高的IL-6水平.
在动物模型中,营养补充剂减少了侵入性瘤形成,并减弱了免疫抑制的微环境,降低了MDSC招募和IL-6表达.

结论:

根据PG-SGA得分,营养不良是HNC患者显著的负预后因素.
营养状况影响抗癌免疫反应,影响关键的免疫抑制细胞和细胞因子.
适当的营养补充剂有可能通过增加抗癌免疫力来改善HNC的预后.

关键词:

头部和部癌症头部和部癌症免疫系统是免疫系统的.营养营养营养营养预后预后预后

相关概念视频

01:21

Cancer Survival Analysis

402

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

402

01:27

Tumor Immunotherapy

577

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

577

01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

02:59

Cancer Prevention

6.2K

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

6.2K

01:30

Cancer Vaccines

437

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

437

02:49

Cancer Therapies

7.8K

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...