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在药物先验帕金森病运动亚型之间,丘脑的结构和功能差异

Yubing Chen¹, Zhiying Guo¹, Yajie Wang¹

¹Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Frontiers in neurology

|June 2, 2023

概括

帕金森病的亚型显示出明显的thalamic结构和功能连接性的变化. 震主导的PD患者表现出改变的连接性,与姿势不稳定和步行困难亚型相比,可能表明补偿机制.

科学领域:

神经科学是一个神经科学.
神经学神经学
放射学放射学是一门学科.

背景情况:

泰拉马斯是运动回路的关键枢纽.
帕金森病 (PD) 呈现出不同的运动亚型,包括震主导 (TD) 和姿势不稳定和步行困难 (PIGD).
了解PD亚型的亚区域性变化对于向治疗至关重要.

研究的目的:

为了调查TD和PD的PIGD亚型之间的thalamic亚区域的结构和功能连接 (FC) 差异.
为了将这些变化与临床运动分数相关联.
评估这些变化在区分PD电机子类型中的潜力.

主要方法:

招募了59名以前没有服用过药物的PD患者 (24名TD,35名PIGD) 和37名健康对照 (HC).
使用FreeSurfer进行thalamic和亚区域体积计算.
进行休息状态功能性MRI (rsfMRI) 进行thalamic亚区域的FC分析.

主要成果:

与PIGD患者相比,TD患者的左后壁面体 (PPtha) 体积明显较低.
与PIGD患者和HCs相比,TD患者在thalamic亚区域和特定皮质区域 (MTG,SFGdl,MOG,STG) 之间显示出更高的FC.
与HCs相比,PIGD患者在thalamic亚区域和左MTG之间表现出较低的FC.
改变的FC与临床症状相关,并有效区分PD运动亚型.

结论:

在TD患者中增加的FC可能表明增加了对感官集成的补偿能力.
thalamus和MTG之间的改变FC可以作为区分PD运动亚型的潜在生物标志物.

关键词:

帕金森病是帕金森氏症的一种疾病.没有使用过毒品的新手.功能性核磁共振成像 (MRI) 功能性核磁共振成像发动机子类型发动机子类型泰拉姆斯 (thalamus) 是一个神经系统.

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