在患有阻塞性睡眠呼吸暂停的儿童中,大脑灰质体积的改变
Chenyi Yu1, Yuchuan Fu2, Yi Lu2
1Department of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Frontiers in neurology
|June 2, 2023
概括
患有阻塞性睡眠呼吸暂停 (OSA) 的儿童表现出前额皮质灰质量变化,影响注意力等认知功能. 这项神经成像研究突出显示了大脑的功能.
科学领域:
- 神经成像是一种神经成像.
- 儿科睡眠医学 儿科睡眠医学
- 认知神经科学 认知神经科学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 显著影响儿童的认知功能.
- 儿科OSA认知障碍的潜在神经成像机制尚不清楚.
研究的目的:
- 研究OSA儿童与非OSA儿童之间局部灰质体积 (GMV) 的差异.
- 探索改变的GMV与认知功能以及OSA严重程度之间的相关性.
主要方法:
- 8岁至13岁的83名儿童 (52名OSA,31名非OSA) 接受了MRI扫描.
- 基于voxel的形态测量 (VBM) 分析了局部GMV;用Das-Naglieri认知评估系统 (DN:CAS) 评估认知功能.
- 统计分析包括两个样本的t测试和皮尔森相关性来比较组和评估关联.
主要成果:
- 与非OSA儿童相比,患有OSA的儿童在右侧中额椎 (MFG_R) 中表现出较大的灰质体积.
- 在Word Series中,OSA儿童的得分较低,表达式注意力得分与MFG_R GMV之间呈负相关性.
- 在OSA严重程度 (OAHI) 和MFG_R GMV.之间没有发现显著的相关性.
结论:
- 额叶皮层灰质发育,特别是与注意力相关的区域,对儿童的OSA敏感.
- 这些发现提供了神经成像证据,支持儿童OSA的认知障碍.
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