语言功能障碍与老年人没有由粉样蛋白病理介导的痴呆症的认知障碍相关
Chunchen Xiang1, Weiping Ai2, Yumei Zhang3,4,5
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Frontiers in neurology
|June 2, 2023
概括
语言衰退预测了阿尔茨海默病 (AD) 的进展. 语义流利性和命名变化与粉样蛋白和蛋白病理有关,提供早期检测见解.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
背景情况:
- 非侵入性语言生物标志物有助于早期发现阿尔茨海默病 (AD).
- 随着时间的推移,语言功能障碍在诊断群体中显示异质性.
研究的目的:
- 分析非痴呆症个体的纵向语言变化.
- 研究语言衰退与神经病理标志物之间的联系.
- 探索阿尔茨海默病生物标志物的语言功能调解效应.
主要方法:
- 利用了阿尔茨海默病神经成像计划 (ADNI) 的数据.
- 分析了272名参与者的语义流利性和对抗命名.
- 对阿尔茨海默病生物标志物 (粉样β,tau) 进行中介分析.
主要成果:
- 语义流和命名的加速下降与MCI/AD进展相关.
- 与粉样β沉积相关的语义流性下降.
- 与粉样β和负担相关的对抗命名下降.
- 粉样β聚合部分介导了这两种语言测量.
结论:
- 语言功能障碍的变化部分是由于粉样蛋白β沉积造成的.
- 对抗命名下降也可能源于增加的tau负担.
- 语言功能障碍是轻度认知障碍和痴呆症的关键临床预测因素.
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