在化品配方中,以胆化为基础的深度浸泡溶剂作为金属蛋白酶 (原酶和弹性酶) 抑制剂
Filipe Smith Buarque1, Silas Arandas Monteiro E Silva2, Bernardo Dias Ribeiro1
1Biochemical Engineering Department, School of Chemistry, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos, 149, Ilha do Fundão, Rio de Janeiro, 21941-909 Brazil.
3 Biotech
|June 2, 2023
概括
深度乳化溶剂 (DES) 显示出作为抗衰老化品的积极作用. 这些绿色溶剂有效抑制原酶和弹性酶,为护肤配方提供可持续的替代品.
科学领域:
- 绿色化学与工程 绿色化学与工程
- 化品科学 化品科学
- 生物化学 生物化学
背景情况:
- 绿色化学和工程在化学产品生命周期中提供可持续的替代方案.
- 深度乙溶剂 (DES) 被公认为具有可调节性质的绿色溶剂.
- 越来越多的DES被用于各种行业的应用,包括化品.
研究的目的:
- 评价深层阳溶剂 (DES) 作为化品中的抗衰老活性剂.
- 评估DES在体外抑制细胞外矩阵金属蛋白酶 (原酶和弹性酶) 的情况.
- 为了确定包含DES的化品配方的稳定性.
主要方法:
- 合成和测试了两个DES (胆化物/甘油和胆化物/尿素).
- 进行了体外测试,以测量原酶和弹性酶的抑制.
- 使用平均立方体直径和室温储存试验来评估配方稳定性.
主要成果:
- 基于ChCl/尿素和ChCl/葡萄糖的DES显示出高抑制原酶 (91.1%和92.7%) 和弹性酶 (49.8%和45.7%).
- 纯尿素显示出显著的弹性酶抑制 (66%),可能是由于结合.
- 基于ChCl/糖的配方表现出良好的稳定性,在细胞结构上没有显著的变化.
结论:
- 深层欧特基溶剂 (DES) 是用于化品应用的有效抗衰老剂.
- DES为传统化品提供了一种可持续且有效的替代品.
- 需要对DES在化品配方中的稳定性和有效性进行进一步的研究.
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