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在停止重度饮酒之前和之后,艾滋病毒感染者休息状态连接

Joseph M Gullett¹, Jason DeFelice¹, Veronica L Richards^2,3

¹Center for Cognitive Aging and Memory, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States.

Frontiers in psychiatry

|June 2, 2023

概括

减少30天的酒精使用改善了艾滋病毒感染者和没有艾滋病毒感染者的大脑连接. 下 Salience 网络连接预测了更大的酒精减少,这表明成功干预的潜在生物标志物.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
成研究研究成研究

背景情况:

过度饮酒会对艾滋病毒感染者 (PLWH) 的神经功能产生负面影响.
实验诱导的酒精减酒是否有可能逆转这些神经效应仍然不清楚.
了解这些影响对于开发针对PLWH的有针对性的干预措施至关重要.

研究的目的:

为了确定30天的戒酒/减酒对静止状态功能连接性的影响.
在艾滋病毒感染者和未感染者身上研究这些影响.
探索酒精使用,减少,艾滋病毒状态和大脑连接之间的关系.

主要方法:

35名重度饮酒者 (48.6% PLWH) 尝试使用应急管理 (CM) 进行30天的戒断/减酒.
休息状态功能性MRI (rsfMRI) 在基线和干预后获得.
在五个主要的rsfMRI网络中分析了功能连接,检查了与客观 (TAC/SCRAM) 和自我报告 (TLFB) 酒精使用的关联.

主要成果:

较高的基线自我报告的酒精使用与增加的背部注意网络 (DAN) 连接性相关.
下 Salience 网络连接预测了更大的客观饮酒减少.
网络之间的连接性增加 (边缘和前端-平行控制) 与更大的酒精减少有关.
具有较低基线DAN连接的PLWH显示出较差的酒精减少结果.

结论:

下 Salience 网络连接可以作为一种生物标志物,用于减少对酒精使用线索的敏感性.
干预后网络之间的连接性增加表明,减少饮酒对大脑有积极的益处.
应急管理可能对低基线DAN连接的PLWH中酒精减少效果较差.

关键词:

使用酒精使用酒精使用酒精停止停止的时间.应急管理应急管理人类免疫缺陷病毒人类免疫缺陷病毒静止状态的功能磁共振成像技术

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