Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Bone Disorders01:29

Bone Disorders

3.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.7K
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

100
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
100
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

106
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
106
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

773
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
773
Schizophrenia01:17

Schizophrenia

158
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
158

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Homozygosity in the <i>APOE</i> 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics.

Frontiers in endocrinology·2020
Same author

Analysis of Family Functioning and Parent-Child Relationship between Adolescents with Depression and their Parents.

Shanghai archives of psychiatry·2018
Same author

Low prevalence of lipid metabolism abnormalities in APOE ε2-genotype and male patients 60 years or older with schizophrenia.

BMC psychiatry·2017
Same author

Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1.

Expert opinion on therapeutic patents·2017
Same author

Production of stable and sensitive SERS substrate based on commercialized porous material of silanized support.

Talanta·2017
Same author

Fermentation quality and nutritive value of total mixed ration silages based on desert wormwood (Artemisia desertorum Spreng.) combining with early stage corn.

Animal science journal = Nihon chikusan Gakkaiho·2017
Same journal

Adaptive memristor-based LIF neuron circuit for energy efficient SNN crossbar array.

Cognitive neurodynamics·2026
Same journal

Dynamic bi-domain discriminator adversarial network for EEG emotion recognition.

Cognitive neurodynamics·2026
Same journal

Olfactory Perception and Neural Rhythms: A Simulation-Based EEG Analysis Using Power Spectral Density FeaturesOlfactory perception and neural rhythms: a simulation-based eeg analysis using power spectral density features.

Cognitive neurodynamics·2026
Same journal

An event-related potentials account of brain predictive coding.

Cognitive neurodynamics·2026
Same journal

A recurrent neural network model for a decision-making task based on sequential evidence accumulation.

Cognitive neurodynamics·2026
Same journal

Synaptic neurotransmitter concentration modulation during learning in bio-inspired spiking neural network.

Cognitive neurodynamics·2026
查看所有相关文章

相关实验视频

Updated: Jul 28, 2025

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex
04:58

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex

Published on: December 3, 2021

6.5K

慢性精神分裂症老年人骨形态遗传蛋白6和骨头蛋白的水平下降

Lin Sun1, Qi Qiu1, Chunxia Ban2

  • 1Department of Geriatric Psychiatry, Alzheimer's Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wanping Road, Xuhui Distinct, Shanghai, People's Republic of China.

Cognitive neurodynamics
|June 2, 2023
PubMed
概括
此摘要是机器生成的。

慢性精神分裂症 (SCZ) 的老年人,特别是痴呆症患者的血液BMP6和noggin水平较低. 这些标志物与SCZ患者的认知功能相关.

关键词:
在这里,APOEOE是APOE.BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6 BMP6痴呆症是一种痴呆症.在 Noggin Noggin 的位置上.精神分裂症是一种精神分裂症.

更多相关视频

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

942
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.4K

相关实验视频

Last Updated: Jul 28, 2025

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex
04:58

Rapid Golgi Stain for Dendritic Spine Visualization in Hippocampus and Prefrontal Cortex

Published on: December 3, 2021

6.5K
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

942
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.4K

科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生化学
  • 老年病的医生 老年病的医生

背景情况:

  • 慢性精神分裂症 (SCZ) 会增加老年人的痴呆风险.
  • 骨形态遗传蛋白6 (BMP6) 和骨头蛋白与痴呆症病理生理学有关.
  • 在SCZ和认知衰退中研究BMP6/noggin对于了解疾病进展至关重要.

研究的目的:

  • 为了检查血液BMP6/noggin水平和慢性SCZ的老年患者的认知功能之间的关联.
  • 为了比较慢性SCZ患者和健康对照者的BMP6/noggin水平.
  • 探索阿波利波蛋白E (APOE) 基因型对SCZ中BMP6水平的影响.

主要方法:

  • 在159名老年SCZ患者和171名健康对照人群中评估了血液BMP6,脑袋和认知功能.
  • 在157名参与者身上进行了Apolipoprotein E (APOE) 基因定型.
  • 在208名参与者的1年随访后,重新评估了认知功能.

主要成果:

  • 老年SCZ患者的血液BMP6和脑袋水平低于对照组,SCZ患有痴呆症患者的水平最低.
  • 结合BMP6和noggin水平可以将SCZ患者与健康对照区分开来.
  • 与非载体相比,具有SCZ的APOE ε4载体降低了BMP6水平.

结论:

  • 血液中的BMP6和noggin水平与慢性SCZ的老年人认知表现有显著的关联.
  • BMP6和noggin可能作为慢性精神分裂症认知障碍的潜在生物标志物.
  • 这些发现突出了BMP6/noggin在SCZ认知衰退的神经生物学基础中的作用.