慢性精神分裂症老年人骨形态遗传蛋白6和骨头蛋白的水平下降
Lin Sun1, Qi Qiu1, Chunxia Ban2
1Department of Geriatric Psychiatry, Alzheimer's Disease and Related Disorders Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 South Wanping Road, Xuhui Distinct, Shanghai, People's Republic of China.
Cognitive neurodynamics
|June 2, 2023
概括
慢性精神分裂症 (SCZ) 的老年人,特别是痴呆症患者的血液BMP6和noggin水平较低. 这些标志物与SCZ患者的认知功能相关.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 老年病的医生 老年病的医生
背景情况:
- 慢性精神分裂症 (SCZ) 会增加老年人的痴呆风险.
- 骨形态遗传蛋白6 (BMP6) 和骨头蛋白与痴呆症病理生理学有关.
- 在SCZ和认知衰退中研究BMP6/noggin对于了解疾病进展至关重要.
研究的目的:
- 为了检查血液BMP6/noggin水平和慢性SCZ的老年患者的认知功能之间的关联.
- 为了比较慢性SCZ患者和健康对照者的BMP6/noggin水平.
- 探索阿波利波蛋白E (APOE) 基因型对SCZ中BMP6水平的影响.
主要方法:
- 在159名老年SCZ患者和171名健康对照人群中评估了血液BMP6,脑袋和认知功能.
- 在157名参与者身上进行了Apolipoprotein E (APOE) 基因定型.
- 在208名参与者的1年随访后,重新评估了认知功能.
主要成果:
- 老年SCZ患者的血液BMP6和脑袋水平低于对照组,SCZ患有痴呆症患者的水平最低.
- 结合BMP6和noggin水平可以将SCZ患者与健康对照区分开来.
- 与非载体相比,具有SCZ的APOE ε4载体降低了BMP6水平.
结论:
- 血液中的BMP6和noggin水平与慢性SCZ的老年人认知表现有显著的关联.
- BMP6和noggin可能作为慢性精神分裂症认知障碍的潜在生物标志物.
- 这些发现突出了BMP6/noggin在SCZ认知衰退的神经生物学基础中的作用.
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