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改善甲状腺激素系统干扰对人类健康风险评估的新方法方法 - 一个PARC项目

Louise Ramhøj¹, Marta Axelstad¹, Yoni Baert²

¹Research Group for Molecular and Reproductive Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.

Frontiers in toxicology

|June 2, 2023

概括

目前的甲状腺激素干扰测试不足. 该项目开发了新的方法,包括体外和内策略,以更好地评估化学风险并保护人类发展.

科学领域:

内分泌学在内分泌学.
毒理学毒理学毒理学
化学品风险评估化学品风险评估

背景情况:

目前用于识别甲状腺激素 (TH) 干扰物的方法依赖于动物组织病理学或全身TH水平,缺乏特异性.
对TH干扰的现有新方法方法 (NAM) 不足以进行可靠的化学风险评估,并推断与发育神经毒性等不良结果的因果关系.

研究的目的:

开发和改进用于识别甲状腺激素系统破坏者的NAM,重点关注与人类相关的途径.
在体内表征有针对性的胚胎,体外,体和化学试验战略的活体作用机制.
通过整合非哺乳动物脊椎动物和人类衍生的体外试验来解决TH破坏的物种差异.

主要方法:

描述甲状腺激素干扰的体内机制.
开发和完善与人类相关的体外试验系统.
包括多种物种 (非哺乳动物脊椎动物,大鼠) 和体外测试.

主要成果:

目前正在开发用于甲状腺激素干扰的NAM.
专注于与人类相关的体外系统和机械学理解.
多种物种的整合以捕捉物种间的变异性.

结论:

增强的NAM对于准确评估甲状腺激素破坏者的化学风险至关重要.
需要一系列全面的测试,包括体外和体内方法.
了解物种差异是保护人类健康免受TH破坏的关键.

关键词:

在 PARC PARC 里面,负面结果的途径.化学品是一种化学品.内分泌干扰干扰内分泌系统非动物试验方法的非动物试验方法监管毒理学监管毒理学甲状腺功能障碍甲状腺功能障碍

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