一个现实研究,及时评估糖尿病黄斑难治于内抗VEGF治疗的真实世界研究
Tsung-Cheng Hsieh1, Guang-Hong Deng2, Yung-Ching Chang3
1Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
Frontiers in endocrinology
|June 2, 2023
概括
光学连贯断层扫描 (OCT) 生物标志物可以预测糖尿病黄斑 (DME) 的治疗反应. 部分连续的内段-外段 (IS-OS) 层表明对抗血管内皮生长因子 (VEGF) 治疗的反应更好,而视网膜 (ERM) 则表明结果更差.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 生物标志物 生物标志物
背景情况:
- 糖尿病黄斑 (DME) 需要早期识别才能有效治疗.
- 静脉内抗血管内皮生长因子 (VEGF) 治疗是对DME的常见治疗方法.
- 鉴定抗VEGF治疗耐受性DME的生物标志物对于个性化治疗至关重要.
研究的目的:
- 研究光学连贯性断层扫描 (OCT) 生物标志物,预测DME患者对抗VEGF治疗的反应.
- 为了确定与抗VEGF治疗耐火的DME相关的OCT特征.
主要方法:
- 从44名从未接受过治疗的DME患者的72只眼睛的回顾性审查.
- 对特定生物标志物进行预处理OCT扫描的评估,包括IS-OS完整性,ERM和玻璃瘤引力.
- 与最佳校正视敏度 (BCVA) 和抗VEGF治疗后的中央黄斑厚度变化相关联的OCT发现.
主要成果:
- 部分连续的内段-外段 (IS-OS) 层是对抗VEGF治疗更好的BCVA反应的重要预测因素 (P<0.001).
- 视网膜 (ERM) 存在 (P=0.015) 和玻璃瘤引力 (P=0.015) 是BCVA反应不佳的显著预测因素.
- 虽然观察到趋势,但CTCT预测的中央黄斑厚度减少与BCVA改善没有显著相关.
结论:
- 在OCT上部分连续的IS-OS层可以预测DME患者对抗VEGF治疗的更好反应.
- 视网膜膜 (ERM) 是在DME中对抗VEGF治疗反应不佳的重要预测因素.
- 海外国家和地区的生物标志物可以帮助预测DME的治疗结果.
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