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在体内,ZIF-8的生物相容性通过鼻内注射缓释

Sneha Kumari1, Thomas S Howlett1, Ryanne N Ehrman1

  • 1Department of Chemistry and Biochemistry, The University of Texas at Dallas 800 West Campbell Rd. Richardson TX 75080 USA Sneha.kumari@utdallas.edu gassensmith@utdallas.edu.

Chemical science
|June 2, 2023
PubMed
概括

酸伊米达酸框架-8 (ZIF-8) 在哺乳动物中显示出有前途的生物安全性,鼻内注射对肺功能,血清蛋白质或组织形态没有显著影响,即使在鼻液中降解.

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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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