通过催化C-H激活近红外化基尼特罗二醇进行晚期类标记

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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells

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Tsuyoshi Oyama1, Lorena Mendive-Tapia2, Verity Cowell2

  • 1Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen Tammanstraße 2 37077 Göttingen Germany lutz.ackermann@chemie.uni-goettingen.de.

Chemical science
|June 2, 2023
PubMed
概括

研究人员开发了一种使用催化剂以光标记的新方法. 这种技术可以创建近红外 (NIR) 探测器,用于改进分子成像和药物发现应用.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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