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通过新辅助化疗保护膀,随后对肌肉侵入性膀癌同时进行化疗

Dalia Hamouda Elsayed¹, Ola M Elfarargy¹, Mohamed Salah Elderey²

¹Medical Oncology Department, Zagazig University, Zagazig, Egypt.

Contemporary oncology (Poznan, Poland)

|June 2, 2023

概括

膀保护疗法显示了肌肉侵入性膀癌 (MIBC) 患者拒绝激进囊切除术的有希望的生存率. 这种方法提供了与标准治疗相比的生存率,改善了生活质量,因此需要进一步研究.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科

背景情况:

膀癌 (BC) 是埃及的一个重大健康问题,特别是在男性中.
肌肉侵入性膀癌 (MIBC) 通常需要激进囊切除术 (RC),这是一个主要的手术程序.
新辅助化疗 (NACT) 和化学辐射疗法 (CCRT) 正在成为MIBC的替代方案.

研究的目的:

为了评估膀保护治疗在MIBC患者的疗效,谁下降了RC.
评估这一患者队列的生存结果和生活质量.

主要方法:

34名拒绝RC的BC患者接受了膀瘤的穿尿管切除 (TURBT),随后进行了NACT (gemcitabine,cisplatin).
实现完全或部分反应的患者接受了与西斯普拉丁同时进行的化学辐射疗法 (CCRT).
结果受到监测,随访时间中位数为46个月.

主要成果:

27名患者 (79.45%) 在NACT后接受了CCRT.
无病生存率为70.8%,三年总生存率为65.1%.
23名患者 (67.6%) 在最后一次随访时还活着,表明没有转移的良好生存率.

结论:

膀保护疗法提供了与MIBC激进囊切除术可比的生存率.
这种方法可以提高膀癌患者的生活质量.
需要进行更大规模的多中心试验来验证这些发现.

关键词:

膀的保护膀的保护同时进行化学或放射治疗.肌肉侵入性膀癌是一种肌肉侵入性膀癌.新辅助性化疗是一种新辅助性化疗.

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