长期暴露于皮质丸激素会破坏的肝脏和肠道胆酸代谢
Lei Wu1, Xinyi Liu1, Aijia Zhang1
1Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Frontiers in veterinary science
|June 2, 2023
概括
慢性皮质 (Cort) 暴露在中,通过破坏胆酸 (BA) 代谢和改变肠道微生物群,诱导脂肪肝. 这种应激反应会影响脂质代谢和微生物平衡,导致肝脏疾病.
科学领域:
- 动物生理学 动物生理学
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 慢性压力会增加皮质糖类,破坏脂质代谢,导致非酒精性脂肪肝疾病.
- 胆汁酸 (BA),在肝脏中合成并由肠道微生物群代谢,对于脂质代谢至关重要.
研究的目的:
- 调查慢性皮质 (Cort) 暴露对的胆酸代谢和肠道微生物群组成的影响.
主要方法:
- 被用皮质 (Cort) 治疗了14天,以模拟慢性压力.
- 分析了肝脏和血的脂质含量,肝脏组织学,胆酸概况 (UPLC-HRMS),与胆酸合成和调节相关的基因表达,以及肠道微生物群组成 (16s测序).
主要成果:
- 科尔特诱导脂肪肝,增加血和肝脏甘油三,改变胆酸概况,降低肝脏CDCA,T-alpha-MCA和T-beta-MCA水平,同时增加便总胆酸 (TBA).
- 科特减少了参与胆酸合成,结合和调节的基因的表达,并显著改变了肠道微生物群的组成,减少了像Lachnospiraceae这样的有益细菌,增加了机会性病原体.
- 斯皮尔曼相关性分析显示了便TBA和特定细菌丰度之间以及肝脏TBA与其他细菌群体之间存在显著的相关性.
结论:
- 慢性皮质暴露会破坏的肝脏和肠道胆酸代谢.
- 这种干扰会诱导肠道微生物组失调,可能有助于脂肪肝疾病的发展.
相关概念视频
01:17Chronic Bowel Disorders: Introduction
493
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
493
01:24Chronic Pancreatitis I: Introduction
117
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
117
01:17Hepatic Drug Excretion: Enterohepatic Cycling
1.6K
Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
1.6K