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动态因果建模显示,在恐惧灭绝过程中,小脑 - 周水管灰色通信增加

Elena Paci¹, Bridget M Lumb¹, Richard Apps¹

¹School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, United Kingdom.

Frontiers in systems neuroscience

|June 2, 2023

概括

恐惧灭绝涉及小脑中间核 (MCN) 和腹侧周水管灰 (vlPAG) 之间的通信. 增加MCN到vlPAG信息流与减少结相关,这表明小脑参与预测恐惧灭绝过程.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
计算神经科学是一种神经科学.

背景情况:

恐惧灭绝对于调节防御行为和生存至关重要.
小脑中枢核 (MCN) 和腹侧周水管灰 (vlPAG) 具有双向连接,并参与恐惧调节.
在恐惧灭绝期间,MCN和vlPAG之间的确切通信动态尚不清楚.

研究的目的:

调查MCN和vlPAG在听觉暗示条件下的恐惧检索和老鼠灭绝过程中的有效连接.
为了确定这些大脑区域之间的通信强度在灭绝试验中如何变化.
在恐惧灭绝期间,将MCN-vlPAG通信的变化与结行为联系起来.

主要方法:

利用动态因果模型 (DCM) 来推断MCN和vlPAG之间的有效连接.
从MCN和vlPAG同时记录的听觉事件相关潜力 (ERP).
采用参数实证贝叶斯分析 (PEB) 来评估信息流和突触功效.

主要成果:

发现MCN与vlPAG信息流和灭绝期间的结行为之间存在反向关系.
证明,随着恐惧灭绝的进展,MCN与vlPAG的通信增加.
确定了从MCN到vlPAG作为关键机制的增强突触疗效.

结论:

这些发现支持小脑在潜在恐惧灭绝的预测过程中的作用.
增加的MCN-vlPAG通信是成功的恐惧记忆灭绝的神经相关.
这项研究阐明了参与自适应性恐惧调节的神经回路.

关键词:

欧洲经济论坛 (ERP) 是一个欧洲经济论坛.小脑小脑是什么意思动态因果建模 (DCM) 的应用灭绝的灭绝是一种灭绝.恐惧恐惧恐惧恐惧周边水道灰色周边水道灰色

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