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利普罗莱德和托雷林治疗具有特异性中央早熟性青春期的儿童:一种疗效/耐受性比较研究

M Valenzise¹, C Nasso², A Scarfone²

¹Department of Human Pathology and Evolutive Age "Gaetano Barresi", University of Messina, Messina, Italy.

Frontiers in pediatrics

|June 2, 2023

概括

激素释放激素激动剂 (GnRHa),如普罗利德和三素,对中部早发性青春期 (CPP) 有效. 这两种治疗方法都表现出类似的疗效和耐受性,这使得它们成为适合儿童治疗CPP的选择.

科学领域:

儿科内分泌学儿科内分泌学
生殖医学生殖医学
药理学药理学是指药理学的学科.

背景情况:

中部早期青春期 (CPP) 涉及到下丘脑-垂体-阴茎轴的早期激活.
淋巴激素释放激素激动剂 (GnRHa) 是CPP的标准治疗方法,可以抑制青春期的进展.
潜在的副作用和常用的GnRHa,乐普罗立德和托雷林的比较疗效需要调查.

研究的目的:

为了比较leuprolide与triptorelin在治疗中部早期青春期 (CPP) 的疗效和耐受性.
评估GnRHa治疗的临床和放射性结果,并评估两个GnRHa治疗的副作用概况.

主要方法:

一项回顾性研究,涉及110名女孩,在2018年至2020年期间接受普罗化德 (n=48) 或托雷林 (n=62) 治疗.
通过临床参数和放射学变化评估的有效性.
系统地记录了副作用,以比较普罗立德和托雷林的安全性.

主要成果:

基线特征没有显著差异,除了在托雷林组中较高的LH和LH峰值水平.
治疗持续时间有显著差异 (普罗立德:971天,三雷林:792天).
41.8%的患者报告了轻微的更年期症状 (27 托雷林,19 普罗利德; p=0.558),具有不同的特定副作用,如头痛和恶心. 增加的初始骨龄与减少的副作用发作相关 (p=0.038).

结论:

普罗利德和托雷林在治疗中部早期青春期 (CPP) 中的疗效和安全性相似.
普罗立德和托雷林之间的选择可以基于个体患者的因素和医生的偏好.
进一步的研究可能会探索长期结果和特定的副作用管理策略.

关键词:

这就是 GnRHa.中央早期青春期早期青春期莱普罗利德 (leuprolide) 是一种一种儿科儿科儿科三重素三重素的使用方法

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