用干细胞进行临床试验的统计研究及其在皮肤伤口中的功能
Linda Mohammadzadeh Boukani1, Rana Ferdowsi Khosroshahi2, Seddigheh Alizadeh Kh2
1Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Cell and tissue research
|June 2, 2023
概括
介酶干细胞 (MSCs) 通过分化为皮肤细胞并释放减少炎症和增强组织再生的因素,促进皮肤伤口愈合. MSC疗法为有效的伤口修复提供了一个有希望的方法.
科学领域:
- 再生医学是一种再生医学.
- 干细胞生物学 干细胞生物学
- 皮肤病学 皮肤病学
背景情况:
- 介质细胞干细胞 (MSCs) 已因其在组织修复中的再生潜力而得到认可.
- 它们的特性包括分化,自我更新,免疫调节,以及在伤口愈合中发挥关键作用.
- 在各种疾病中,MSC被广泛研究用于皮肤伤口修复的应用.
研究的目的:
- 审查介质干细胞 (MSC) 在皮肤伤口愈合中的多方面的作用.
- 综合基础和临床研究中关于 MSCs 在伤口修复中的发现.
- 探索当前和未来的治疗策略,涉及MSC用于伤口管理.
主要方法:
- 来自PubMed,谷歌学者和临床试验数据库的75篇文章的系统审查.
- 在2000年至2022年期间进行的文献搜索.
- 对研究的分析,重点是MSC机制和在皮肤伤口愈合中的治疗应用.
主要成果:
- MSCs迁移到伤口部位并参与所有愈合阶段.
- 它们分化为皮肤细胞,并通过膜信号调节愈合,促进血管生成和上皮再生.
- MSCs减少纤维化和收缩,同时增加原和抗拉强度,创造一个有利于愈合的微环境.
结论:
- 介酶干细胞 (MSCs) 有效地通过分化和膜机制促进皮肤伤口愈合.
- 先进的输送方法,如注射,喷雾,水凝和细胞外囊泡,提高MSC的疗效.
- 对基于MSC的治疗方法的进一步研究有望提供更有效的伤口愈合策略.
相关概念视频
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
Stem Cell Therapy for Tissue Regeneration
4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Clinical Trials
6.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.9K
Mesenchymal Stem Cells
4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
Source And Potency Of Stem Cells
5.0K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
5.0K


