运动改善了耳,脸部疼痛,并在帕金森病的老鼠模型中改变了神经的表达
Karina Henrique Binda1,2,3, Marucia Chacur1, Daniel Oliveira Martins4,5
1Department of Anatomy, Laboratory of Functional Neuroanatomy of Pain, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Neurotoxicity research
|June 2, 2023
概括
有氧运动训练在帕金森病 (PD) 鼠标模型中改善了面部疼痛. 这种改善与三系统内与疼痛相关的和大麻素受体的变化有关.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 帕金森病研究 帕金森病研究
背景情况:
- 耳鼻面部疼痛是早期帕金森病 (PD) 的普遍,但管理不善的非运动性症状.
- 了解与PD相关的面部疼痛的神经化学基础对于开发有效的治疗方法至关重要.
研究的目的:
- 为了研究神经化学因素,特别是与疼痛相关的和大麻素受体,在半帕金森症小鼠模型中涉及口腔面部疼痛.
- 评估跑步机运动在缓解面部或口腔疼痛和调节这些神经化学机制方面的有效性.
主要方法:
- 通过单边的6-氧多巴胺 (6-OHDA) 条纹注射建立了一种 hemi-parkinsonian 鼠标模型.
- 动物接受跑步机运动或保持久坐,在训练前和训练期间进行疼痛评估.
- 在三系统中分析了物质P (SP),素基因相关 (CGRP),TRPV1,CB1和CB2受体的表达.
主要成果:
- 单边注射6-OHDA诱导了面腔疼痛,有氧运动训练显著改善了这种疼痛.
- 在PD模型动物中观察到的运动训练逆转了SP,CGRP和TRPV1表达的增加和CB1/CB2受体水平的降低.
- 大麻素受体对抗剂在PD模型动物中加剧了 nociception,证实了它们的参与.
结论:
- 在帕金森病模型中,有氧运动是改善口腔面部疼痛的有效干预措施.
- 运动的治疗效果可能包括调节与疼痛相关的神经和三胞胎系统中的大麻素受体.
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