相关实验视频
Updated: Jul 28, 2025
09:01
A Macrophage-Tumor Spheroid Co-Invasion Assay
Published on: January 24, 2025
668
利用巨介导的癌症免疫疗法通过一个由分子打印的纳米协调器诱导的级联效应
Shuxin Xu1, Zikuan Gu1, Haifeng Lu1
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China.
ACS applied materials & interfaces
|June 2, 2023
概括
这项研究引入了一种新的纳米协调器,用于重新编程瘤相关巨细胞 (TAMs),以加强癌症免疫疗法. 纳米技术有效地准TAM,增强它们的抗瘤功能,而不会影响健康组织.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 重编程瘤相关巨细胞 (TAMs) 是癌症免疫疗法的关键策略.
- 需要有针对性的治疗来增强巨细胞的抗瘤功能,同时保护正常组织.
研究的目的:
- 设计和设计一种用于有针对性的TAM重编程的新型纳米协调器.
- 为增强癌症免疫治疗利用纳米技术和分子印记.
主要方法:
- 设计了一种纳米协调器,具有磁性氧化铁核心和用酸打印的外.
- 使用外部磁铁用于瘤部位积累和酸结合用于瘤细胞向.
- 研究了纳米协调器促进巨细胞化和M1极化的能力.
主要成果:
- 纳米协调器在瘤部位迅速积累,并显示长时间的保留.
- 在瘤细胞上与酸的特异性结合增强了巨细胞的吞细胞.
- 纳米协调器的摄入有效地促进了巨细胞的M1极化,激活了抗瘤免疫力.
结论:
- 开发的纳米协调器通过级联效应有效地重编程TAM,用于强大的巨细胞介导免疫疗法.
- 这种方法利用TAM用于癌症治疗,而不会对系统性或组织居民巨细胞产生不良影响.
相关概念视频
01:27Tumor Immunotherapy
577
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
577
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K